AGI-6780 N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide
AGI-6780
CAS: 1432660-47-3
Molecular Formula: C21H18F3N3O3S2
AGI-6780 N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide - Names and Identifiers
AGI-6780 N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide - Physico-chemical Properties
| Molecular Formula | C21H18F3N3O3S2 |
| Molar Mass | 481.51 |
| Density | 1.52±0.1 g/cm3(Predicted) |
| pKa | 11.78±0.20(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | AGI-6780 can effectively reduce the ectopic overexpression of IDH2/R140Q in cell lines (R)-2-Hydroxyglutaric acid (2HG) level, EC50 is 20 nM, compared with other dehydrogenase, with excellent selectivity. AGI-6780 reverses IDH2/R140Q induced differentiation arrest in TF-1 cells and induces sharp differentiation in primary human IDH2/R140Q AML patient samples. |
AGI-6780 N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.077 ml | 10.384 ml | 20.768 ml |
| 5 mM | 0.415 ml | 2.077 ml | 4.154 ml |
| 10 mM | 0.208 ml | 1.038 ml | 2.077 ml |
| 5 mM | 0.042 ml | 0.208 ml | 0.415 ml |
Last Update：2024-01-02 23:10:35
AGI-6780 N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide - Reference Information
| biological activity | AGI-6780 is a potent selective IDH2 R140Q mutant inhibitor with an IC50 of 23 nM. |
| in vitro study | AGI-6780 can effectively reduce the (R)-2-hydroxyglutaric acid (2HG) level of ectopic overexpression of IDH2/R140Q in cell lines, with EC50 of 20 nM, which has excellent selectivity compared with other dehydrogenases. AGI-6780 reversed IDH2/R140Q-induced differentiation arrest in TF-1 cells and induced sharp differentiation in primary human IDH2/R140QAML patient samples. |
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: AGI-6780 Visit Supplier Webpage Request for quotationCAS: 1432660-47-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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